Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased ge...

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Detalhes bibliográficos

Principais autores:	Madeleine Bossaert, Angélique Pipier, Jean-Francois Riou, Céline Noirot, Linh-Trang Nguyên, Remy-Felix Serre, Olivier Bouchez, Eric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gomez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-06-01
coleção:	eLife
Assuntos:	G-quadruplex CX-5461 topoisomerase 2 DNA breaks transcription
Acesso em linha:	https://elifesciences.org/articles/65184
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