Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased ge...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Madeleine Bossaert, Angélique Pipier, Jean-Francois Riou, Céline Noirot, Linh-Trang Nguyên, Remy-Felix Serre, Olivier Bouchez, Eric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gomez
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	eLife Sciences Publications Ltd 2021-06-01
Saila:	eLife
Gaiak:	G-quadruplex CX-5461 topoisomerase 2 DNA breaks transcription
Sarrera elektronikoa:	https://elifesciences.org/articles/65184
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!