MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer

Abstract Background MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on the surface of natural killer cells (NK cells), B cells, and monocytes. Howeve...

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Principais autores:	Yuliang Wu, Qi Liu, Yan Xie, Jihui Zhu, Sai Zhang, Yao Ge, Jing Guo, Ning Luo, Wei Huang, Runping Xu, Shupeng Liu, Zhongping Cheng
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2023-08-01
Serija:	Journal of Ovarian Research
Teme:	MUC16 Neutrophils Ovarian cancer Tumor immune microenvironment Siglec-9
Online dostop:	https://doi.org/10.1186/s13048-023-01207-0
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