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MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer

Abstract Background MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on the surface of natural killer cells (NK cells), B cells, and monocytes. Howeve...

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Principais autores: Yuliang Wu, Qi Liu, Yan Xie, Jihui Zhu, Sai Zhang, Yao Ge, Jing Guo, Ning Luo, Wei Huang, Runping Xu, Shupeng Liu, Zhongping Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-08-01
coleção:Journal of Ovarian Research
Assuntos:
MUC16
Neutrophils
Ovarian cancer
Tumor immune microenvironment
Siglec-9
Acesso em linha:https://doi.org/10.1186/s13048-023-01207-0
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