Genome-Wide Analysis Identifies Rag1 and Rag2 as Novel Notch1 Transcriptional Targets in Thymocytes

Recombination activating genes 1 (Rag1) and Rag2 are expressed in immature lymphocytes and essential for generating the vast repertoire of antigen receptors. Yet, the mechanisms governing the transcription of Rag1 and Rag2 remain to be fully determined, particularly in thymocytes. Combining cDNA mic...

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Detalhes bibliográficos

Principais autores:	Yang Dong, Hao Guo, Donghai Wang, Rongfu Tu, Guoliang Qing, Hudan Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-07-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	Notch1 dimerization Recombination activating genes T-cell acute lymphoblastic leukemia Double negative thymocyte T-cell development
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2021.703338/full
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