A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9 binding sites in a transfected human cell line a...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J Ross Chapman, A Radu Aricescu, Simon R Myers
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2017-10-01
Serija:	eLife
Teme:	meiosis recombination zinc finger protein transposable elements PRDM9 KRAB
Online dostop:	https://elifesciences.org/articles/28383
Oznake:	Označite Brez oznak, prvi označite!