Mitochondrial Fragmentation Induced by the CFTR Modulators Lumacaftor and Ivacaftor in Immortalized Cystic Fibrosis Cell Lines

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR gene, which encodes a cAMP-activated chloride channel essential for epithelial function. Beyond its canonical role, evidence suggests CFTR also influences mitochondrial function. Previous studies have identified C...

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Bibliografische Detailangaben

Hauptverfasser:	Camila Dib, Pablo A. Iglesias González, María de los Ángeles Aguilar, Guillermo L. Taminelli, Tatiana Limpias del Valle, Nadia E. Nuñez, Analía G. Karadayian, Tomás A. Santa-Coloma, Ángel G. Valdivieso
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2025-10-01
Schriftenreihe:	Cells
Schlagworte:	CFTR lumacaftor ivacaftor mitochondrial morphology
Online-Zugang:	https://www.mdpi.com/2073-4409/14/20/1601
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