Mitochondrial Fragmentation Induced by the CFTR Modulators Lumacaftor and Ivacaftor in Immortalized Cystic Fibrosis Cell Lines

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR gene, which encodes a cAMP-activated chloride channel essential for epithelial function. Beyond its canonical role, evidence suggests CFTR also influences mitochondrial function. Previous studies have identified C...

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Autores principales:	Camila Dib, Pablo A. Iglesias González, María de los Ángeles Aguilar, Guillermo L. Taminelli, Tatiana Limpias del Valle, Nadia E. Nuñez, Analía G. Karadayian, Tomás A. Santa-Coloma, Ángel G. Valdivieso
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-10-01
Colección:	Cells
Materias:	CFTR lumacaftor ivacaftor mitochondrial morphology
Acceso en línea:	https://www.mdpi.com/2073-4409/14/20/1601
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