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Kidins220 regulates the development of B cells bearing the λ light chain

The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220 kDa (Kidins220) as an interaction partner of the BCR. In vivo ablation of Kidins220 in B cells resulted in a marked reduction of λLC-express...

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Autores principales: Anna-Maria Schaffer, Gina Jasmin Fiala, Miriam Hils, Eriberto Natali, Lmar Babrak, Laurenz Alexander Herr, Mari Carmen Romero-Mulero, Nina Cabezas-Wallscheid, Marta Rizzi, Enkelejda Miho, Wolfgang WA Schamel, Susana Minguet
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications Ltd 2024-01-01
Colección:eLife
Materias:
B cells
signalling
recombination
adaptive immunity
lambda light chain
Acceso en línea:https://elifesciences.org/articles/83943
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