Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast, the GAD6...

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Autori principali:	Christopher G. Langendorf, Kellie L. Tuck, Trevor L. G. Key, Gustavo Fenalti, Robert N. Pike, Carlos J. Rosado, Anders S. M. Wong, Ashley M. Buckle, Ruby H. P. Law, James C. Whisstock
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Portland Press 2013-01-01
Serie:	Bioscience Reports
Soggetti:	auto-inactivation catalytic loop chimaera C-terminal domain glutamic acid decarboxylase X-ray crystallography
Accesso online:	http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm
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