Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast, the GAD6...

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Hlavní autoři:	Christopher G. Langendorf, Kellie L. Tuck, Trevor L. G. Key, Gustavo Fenalti, Robert N. Pike, Carlos J. Rosado, Anders S. M. Wong, Ashley M. Buckle, Ruby H. P. Law, James C. Whisstock
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Portland Press 2013-01-01
Edice:	Bioscience Reports
Témata:	auto-inactivation catalytic loop chimaera C-terminal domain glutamic acid decarboxylase X-ray crystallography
On-line přístup:	http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm
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