Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α

Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis. However, the underlying mechanism is still not completely understood. In this study, progranulin (PGRN) was isolated as a key regulator of bone mineral density in postmenopausal women through high throughput p...

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Detalhes bibliográficos

Principais autores:	Guangfei Li, Aifei Wang, Wei Tang, Wenyu Fu, Qingyun Tian, Jinlong Jian, Michal Lata, Aubryanna Hettinghouse, Yuanjing Ding, Jianlu Wei, Xiangli Zhao, Mingyong Wang, Qirong Dong, Chuanju Liu, Youjia Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2025-01-01
Colecção:	Genes and Diseases
Assuntos:	Estrogen receptor α Osteoclastogenesis Postmenopausal osteoporosis Progranulin Ubiquitination
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352304224000187
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