Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation

Abstract One of the histopathological hallmarks of neuroinflammatory diseases such as multiple sclerosis (MS) is the emergence of astrocyte reactivity. Accumulating evidence suggests that excessive glycolysis may lead to astrocyte reactivity and contribute to neuroinflammatory responses. However, th...

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Detalhes bibliográficos

Principais autores:	Luting Yang, Chunqing Hu, Xiaowen Chen, Mengru Sun, Jie Zhang, Zhe Feng, Tingting Cui, Ruyi Zhu, Xin Zhang, Yanxin Xiao, Ye Gong, Yang Yang, Qian Zhang, Yaling Zhang, Yaping Yan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-04-01
coleção:	Journal of Neuroinflammation
Assuntos:	Experimental autoimmune encephalomyelitis Astrocyte Ubiquitination Proliferation Glycolysis
Acesso em linha:	https://doi.org/10.1186/s12974-025-03453-z
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