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Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells

Abstract Upregulation of insulin mRNA translation upon hyperglycemia in pancreatic islet β-cells involves several RNA-binding proteins. Here, we found that G3BP1, a stress granule marker downregulated in islets of subjects with type 2 diabetes, binds to insulin mRNA in glucose concentration-dependen...

Deskribapen osoa

Gorde:
Egile Nagusiak: Esteban Quezada, Klaus-Peter Knoch, Jovana Vasiljevic, Annika Seiler, Akshaye Pal, Abishek Gunasekaran, Carla Münster, Daniela Friedland, Eyke Schöniger, Anke Sönmez, Pascal Roch, Carolin Wegbrod, Katharina Ganß, Nicole Kipke, Simon Alberti, Rita Nano, Lorenzo Piemonti, Daniela Aust, Jürgen Weitz, Marius Distler, Michele Solimena
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Nature 2025-05-01
Saila:The EMBO Journal
Gaiak:
Stress Granules
Insulin
Translation
Islet
Diabetes
Sarrera elektronikoa:https://doi.org/10.1038/s44318-025-00448-7
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