Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells
Abstract Upregulation of insulin mRNA translation upon hyperglycemia in pancreatic islet β-cells involves several RNA-binding proteins. Here, we found that G3BP1, a stress granule marker downregulated in islets of subjects with type 2 diabetes, binds to insulin mRNA in glucose concentration-dependen...
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| Главные авторы: | , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer Nature
2025-05-01
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| Серии: | The EMBO Journal |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1038/s44318-025-00448-7 |
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