BAP1 loss impairs IFN-γ signaling and enhances NK cell-mediated cytotoxicity in myeloid leukemia

Abstract Natural killer (NK) cells recognize and eliminate malignant cells through multiple receptor–ligand interactions. To uncover genetic determinants of the susceptibility of myeloid leukemia cells to NK cell cytotoxicity, we analyzed several genome-wide CRISPR screens. Among recurrent hits, the...

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Xehetasun bibliografikoak

Egile Nagusiak:	Chiara Badami, Erna Islamagic, Linnea Blomén, Frida Svensson, Theebiga Kathirkamanathan, Kristoffer Hellstrand, Elin Bernson, Fredrik B. Thorén
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Springer 2026-06-01
Saila:	Cancer Immunology, Immunotherapy
Gaiak:	NK cells CRISPR/Cas9 BAP1 IFN-γ HLA-I
Sarrera elektronikoa:	https://doi.org/10.1007/s00262-026-04453-5
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