Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Summary: Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators of trans...

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Autors principals:	Andrés Herrero-Ruiz, Pedro Manuel Martínez-García, José Terrón-Bautista, Gonzalo Millán-Zambrano, Jenna Ariel Lieberman, Silvia Jimeno-González, Felipe Cortés-Ledesma
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-04-01
Col·lecció:	Cell Reports
Matèries:	DNA supercoiling DNA topology DNA topoisomerases transcription elongation promoter-proximal pausing gene expression
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124721002916
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