The balance between gyrase and topoisomerase I activities determines levels of supercoiling, nucleoid compaction, and viability in bacteria
Two enzymes are responsible for maintaining supercoiling in the human pathogen Streptococcus pneumoniae, gyrase (GyrA2GyrB2) and topoisomerase I. To attain diverse levels of topoisomerase I (TopoI, encoded by topA), two isogenic strains derived from wild-type strain R6 were constructed: PZntopA, car...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2023-01-01
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| Schriftenreihe: | Frontiers in Microbiology |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1094692/full |
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