Exome Sequence Data of Eight SLC Transporters Reveal That <i>SLC22A1</i> and <i>SLC22A3</i> Variants Alter Metformin Pharmacokinetics and Glycemic Control

<b>Background</b>: Type 2 diabetes (T2D) is one of the leading causes of mortality and is a public health challenge worldwide. Metformin is the first-choice treatment for T2D; its pharmacokinetics (PK) is facilitated by members of the solute carrier (SLC) superfamily of transporters, it is not metab...

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Bibliografische gegevens

Hoofdauteurs:	Monserrat I. Morales-Rivera, Radamés Alemón-Medina, Angélica Martínez-Hernández, Cecilia Contreras-Cubas, Nelly F. Altamirano-Bustamante, Josefina Gómez-Garduño, Elvia C. Mendoza-Caamal, J. Orlando Nuñez-González, Raquel García-Álvarez, Cristina Revilla-Monsalve, José Antonio Valcarcel-Gamiño, José Rafael Villafan-Bernal, Federico Centeno-Cruz, Humberto García-Ortiz, Francisco Barajas-Olmos, Lorena Orozco
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2024-10-01
Reeks:	Pharmaceuticals
Onderwerpen:	metformin response pharmacokinetics pharmacogenetics SLC transporters type 2 diabetes SNVs
Online toegang:	https://www.mdpi.com/1424-8247/17/10/1385
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