Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.
PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy.Here, we investigated the impact of mutations in...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2011-03-01
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| Serija: | PLoS ONE |
| Online dostop: | https://doi.org/10.1371/journal.pone.0016746 |
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