Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

Abstract Background Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia are believed to be key mediators of neuroi...

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Prif Awduron:	Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla, Charles G. Glabe
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2018-03-01
Cyfres:	Molecular Neurodegeneration
Pynciau:	Alzheimer’s disease Amyloid beta Plaques Intraneuronal amyloid Microglia Neuroinflammation
Mynediad Ar-lein:	http://link.springer.com/article/10.1186/s13024-018-0244-x
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