PLX3397 attenuated tumor growth and remodeled tumor microenvironment of recurrent glioblastoma

Abstract The tumor microenvironment (TME) is critically implicated in glioblastoma (GBM) recurrence, therapeutic resistance, and immune evasion. By analyzing both primary and recurrent GBM from Chinese Glioma Genome Atlas (CGGA) and clinical samples, we identified significant differences in TME. To...

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主要な著者:	Chen Yang, Linzhi Cai, Xi Xiang, Xiwei Zhu, Chengli Liu, Jianming Liao, Zhan Zhang, Mingchang Li
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-12-01
シリーズ:	Scientific Reports
主題:	Recurrent glioblastoma Tumor microenvironment Murine glioblastoma model CSF1R inhibit PLX3397
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-32943-6
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