Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Although structurally similar to type II counterparts, type I or activin receptor-like kinases (ALKs) are set apart by a metastable helix–loop–helix (HLH) element preceding the protein kinase domain that, according to a longstanding paradigm, serves passive albeit critical roles as an inhibitor-to-s...

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Egile Nagusiak:	Jay C. Groppe, Guorong Lu, Mary R. Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q. Le, Andria L. Culbert, Eileen M. Shore, Kristi A. Wharton, Frederick S. Kaplan
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2023-07-01
Saila:	Biomolecules
Gaiak:	allosteric regulation bone morphogenetic protein (BMP) serine/threonine kinase ACVR1 ALK2 FKBP12
Sarrera elektronikoa:	https://www.mdpi.com/2218-273X/13/7/1129
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