Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

ABSTRACT Radiotherapy is known to trigger immunogenic cell death and activate local anti‐tumor immune responses. However, its systemic immunomodulatory effects remain poorly understood. Here, we discovered that irradiated tumor cell‐derived microparticles (RT‐MPs) are released into the circulation a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
coleção:	Advanced Science
Assuntos:	extracellular vesicles, irradiated tumor cell‐derived microparticles IL‐1β, neutrophil, radiotherapy
Acesso em linha:	https://doi.org/10.1002/advs.202514390
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!