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Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

Abstract Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytos...

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Main Authors: Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou
Format: Artigo
Language:Inglês
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Vaccinia virus
Cytosine deaminase
Antitumor efficacy
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12935-020-01340-6
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