Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases

Despite the different degrees of blood–brain barrier (BBB) damage in diverse brain diseases, it remains a formidable barrier that restricts most drugs from penetrating the brain. A comprehensive understanding and elucidation of the disease-specific changes of BBB in various brain pathologies are ess...

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Autors principals:	Yun Chen, Xinzhu Sun, Yilong Xi, Zhenyu Luo, Huarong Lai, Dongxin Zhu, Yifan Zhang, Fenglin Xu, Jian Li, Jianping Zhou, Yang Ding, Huaqing Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-04-01
Col·lecció:	Acta Pharmaceutica Sinica B
Matèries:	Blood-brain barrier (BBB) Brain diseases BBB dysfunction Pathophysiological changes Pathology-oriented delivery Drug delivery strategies
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211383525006938
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