Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases

Despite the different degrees of blood–brain barrier (BBB) damage in diverse brain diseases, it remains a formidable barrier that restricts most drugs from penetrating the brain. A comprehensive understanding and elucidation of the disease-specific changes of BBB in various brain pathologies are ess...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yun Chen, Xinzhu Sun, Yilong Xi, Zhenyu Luo, Huarong Lai, Dongxin Zhu, Yifan Zhang, Fenglin Xu, Jian Li, Jianping Zhou, Yang Ding, Huaqing Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-04-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	Blood-brain barrier (BBB) Brain diseases BBB dysfunction Pathophysiological changes Pathology-oriented delivery Drug delivery strategies
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211383525006938
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!