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Tunable protein synthesis by transcript isoforms in human cells

Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profile...

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Principais autores: Stephen N Floor, Jennifer A Doudna
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-01-01
Serier:eLife
Fag:
transcript isoforms
translational control
deep sequencing
engineered translation
RNA processing
RNA-seq
Online adgang:https://elifesciences.org/articles/10921
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