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Single-Dose Intranasal or Intramuscular Administration of Simian Adenovirus-Based H1N1 Vaccine Induces a Robust Humoral Response and Complete Protection in Mice

Despite the widespread accessibility of vaccines and antivirals, seasonal influenza virus epidemics continue to pose a threat to public health. In this study, we constructed a recombinant replication-deficient simian adenovirus type 25 vector carrying the full-length hemagglutinin (HA) of the H1N1 i...

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Asıl Yazarlar: Daria V. Voronina, Irina V. Vavilova, Olga V. Zubkova, Tatiana A. Ozharovskaia, Olga Popova, Anastasia S. Chugunova, Polina P. Goldovskaya, Denis I. Zrelkin, Daria M. Savina, Irina A. Favorskaya, Dmitry V. Shcheblyakov, Denis Y. Logunov, Alexandr L. Gintsburg
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2025-08-01
Seri Bilgileri:Viruses
Konular:
SAd25
ChAd68
adenoviral vector
influenza
H1N1
humoral immunity
Online Erişim:https://www.mdpi.com/1999-4915/17/8/1085
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