Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineered hetero...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Javier García-Nafría, Yang Lee, Xiaochen Bai, Byron Carpenter, Christopher G Tate
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2018-05-01
coleção:	eLife
Assuntos:	structure G protein-coupled receptor GPCR adenosine receptors mini-G protein
Acesso em linha:	https://elifesciences.org/articles/35946
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!