Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineered hetero...

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Dades bibliogràfiques

Autors principals:	Javier García-Nafría, Yang Lee, Xiaochen Bai, Byron Carpenter, Christopher G Tate
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2018-05-01
Col·lecció:	eLife
Matèries:	structure G protein-coupled receptor GPCR adenosine receptors mini-G protein
Accés en línia:	https://elifesciences.org/articles/35946
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