Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

BackgroundSomatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides are presented on MHC class II (MHCII) vi...

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Hlavní autoři:	Peter Symonds, Ana Marcu, Katherine W. Cook, Rachael L. Metheringham, Lindy G. Durrant, Victoria A. Brentville
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-11-01
Edice:	Frontiers in Immunology
Témata:	CD4 T cell citrulline cancer immunotherapy peptide elution post-translational modification (PTM)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.764462/full
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