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Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy

IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which permits the presentation of modified epitopes upon M...

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Principais autores: Victoria Anne Brentville, Peter Symonds, JiaXin Chua, Anne Skinner, Ian Daniels, Katherine Wendy Cook, Sasa Koncarevic, Roxana Martinez-Pinna, Sabaria Shah, Ruhul Hasan Choudhury, Poonam Vaghela, Daisy Weston, Abdullah Al-Omari, James Davis, Lindy G. Durrant
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-12-01
Serier:Frontiers in Immunology
Fag:
citrullination
cancer
MHC-II
post-translation modifications
GRP78
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066185/full
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