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Fatty acid desaturation and lipoxygenase pathways support trained immunity

Abstract Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity. Here, we show that monocytes with a trained immunity phenotype, due to exposure to the Bacillus Calmette-Guérin (BCG) vaccine, are cha...

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Autores principales: Anaísa V. Ferreira, Juan Carlos Alarcon-Barrera, Jorge Domínguez-Andrés, Özlem Bulut, Gizem Kilic, Priya A. Debisarun, Rutger J. Röring, Hatice N. Özhan, Eva Terschlüsen, Athanasios Ziogas, Sarantos Kostidis, Yassene Mohammed, Vasiliki Matzaraki, George Renieris, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Martin Giera
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2023-11-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-023-43315-x
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