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Homocysteine-Mediated Neuronal Pyroptosis Contributes to Brain Injury in Heatstroke Rats by Activating the m<sup>6</sup>A-YTHDF2-NLRP3 Pathway

Heat stroke (HS) is a life-threatening condition that leads to neuronal injury, particularly in the prefrontal cortex, though its mechanisms remain unclear. In this study, we established a rat HS model and observed significant inflammatory responses and neuronal pyroptosis in the prefrontal cortex 6...

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Principais autores: Shijia Zhang, Fang Xie, Xue Wang, Zhaowei Sun, Ling Zhang, Weiwei Liu, Xiaobing Chen, Lingjia Qian, Yun Zhao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Cells
Fag:
heat stroke
pyroptosis
prefrontal cortex
homocysteine
NLRP3
PC12 cell line
Online adgang:https://www.mdpi.com/2073-4409/14/18/1437
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