Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

Abstract Lysosomal entrapment is a formidable bottleneck for the delivery of clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) gene editing systems. To address this, we developed a nanoneedle platform that are self‐assembled by CRISPR/Cas9 encoding plas...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2026-03-01
Sarja:	BMEMat
Aiheet:	anti‐tumor therapy CRISPR/Cas9 lysosomal escape nanoneedles transformable nanoparticles
Linkit:	https://doi.org/10.1002/bmm2.70032
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