Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression

The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplifying RNA (taRNA), whereas miRNA delivery typically...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Ayşegül Yıldız, Aida Hasani, Tina Hempel, Nina Köhl, Aline Beicht, René Becker, Stefanie Hubich-Rau, Martin Suchan, Marco A. Poleganov, Ugur Sahin, Tim Beissert
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-06-01
Edice:	Molecular Therapy: Nucleic Acids
Témata:	MT: Delivery Strategies non-viral RNA vector trans-amplifying RNA miRNA delivery gene regulation trans-replication
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2162253124000490
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!