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Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression

The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplifying RNA (taRNA), whereas miRNA delivery typically...

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Principais autores: Ayşegül Yıldız, Aida Hasani, Tina Hempel, Nina Köhl, Aline Beicht, René Becker, Stefanie Hubich-Rau, Martin Suchan, Marco A. Poleganov, Ugur Sahin, Tim Beissert
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-06-01
coleção:Molecular Therapy: Nucleic Acids
Assuntos:
MT: Delivery Strategies
non-viral RNA vector
trans-amplifying RNA
miRNA delivery
gene regulation
trans-replication
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253124000490
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