SPT6 loss permits the transdifferentiation of keratinocytes into an intestinal fate that resembles Barrett’s metaplasia

Summary: Transient depletion of the transcription elongation factor SPT6 in the keratinocyte has been recently shown to inhibit epidermal differentiation and stratification; instead, they transdifferentiate into a gut-like lineage. We show here that this phenomenon of transdifferentiation recapitula...

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Hauptverfasser:	Daniella T. Vo, MacKenzie R. Fuller, Courtney Tindle, Mahitha Shree Anandachar, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-10-01
Schriftenreihe:	iScience
Schlagworte:	Molecular biology Cell biology Bioinformatics
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004221010890
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