CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells

Summary: The in vitro recapitulation of chromosomal rearrangements is a necessary tool for understanding malignancy at the molecular level. Here, we describe the targeted induction of a large chromosomal inversion (>3.7 Mbp) through CRISPR-Cas9-mediated genome editing. As inversions occur at low fre...

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Detalhes bibliográficos

Principais autores:	Andriani Angelopoulou, Angelos Papaspyropoulos, Argyris Papantonis, Vassilis G. Gorgoulis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-06-01
coleção:	STAR Protocols
Assuntos:	Cell Biology Cell culture Single Cell Flow Cytometry/Mass Cytometry Cancer Sequencing
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S266616672200137X
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