Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models

Abstract Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key challenges in developing effective therapeutics is the poor translation of preclinical models used in the drug discovery pipeline. This leaves drug attrition rates and costs at an unacceptably high level....

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Hlavní autoři:	Melica Nourmoussavi Brodeur, Kayla Simeone, Kim Leclerc-Deslauniers, Hubert Fleury, Euridice Carmona, Diane M. Provencher, Anne-Marie Mes-Masson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2021-09-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-021-97434-w
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