Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+

Abstract Tpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of tRNA. In mammals and bacteria, Tpt1-cata...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Chulei Cao, Jie Yang, Weizhen Zhang, Jiaqin Chen, Yanqing Gao, Yuqi Yao, Yixi Zhang, Huili Li, Linxi Li, Zhaorong Luo, Chenxi Wang, Guangli Tang, Ruixue Cui, Hehua Liu, Qiyao Wang, Zhen Huang, Jinbiao Ma, Jianhua Gan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-12-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-025-65881-y
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!