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Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides

Abstract Background Fungal cyclodepsipeptides (CDPs) are non-ribosomally synthesized peptides produced by a variety of filamentous fungi and are of interest to the pharmaceutical industry due to their anticancer, antimicrobial and anthelmintic bioactivities. However, both chemical synthesis and isol...

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Main Authors: Simon Boecker, Stefan Grätz, Dennis Kerwat, Lutz Adam, David Schirmer, Lennart Richter, Tabea Schütze, Daniel Petras, Roderich D. Süssmuth, Vera Meyer
Format: Artigo
Language:Inglês
Published: BMC 2018-03-01
Series:Fungal Biology and Biotechnology
Subjects:
Aspergillus niger
Natural products
Non-ribosomal peptide synthetase
Tet-on
Enniatin
Beauvericin
Online Access:http://link.springer.com/article/10.1186/s40694-018-0048-3
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