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Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of...

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Autori principali: Sundeep Chaitanya Vedithi, Carlos H.M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L. Blundell, Sony Malhotra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science (AAAS) 2020-01-01
Serie:Computational and Structural Biotechnology Journal
Soggetti:
Mutation Coolspots
Mycobacterium leprae
In-silico Saturation Mutagenesis
Thermodynamic stability
Rifampin
RNA Polymerase
Accesso online:http://www.sciencedirect.com/science/article/pii/S2001037019302910
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