Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of...

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Detalhes bibliográficos

Principais autores:	Sundeep Chaitanya Vedithi, Carlos H.M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L. Blundell, Sony Malhotra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Association for the Advancement of Science (AAAS) 2020-01-01
Colecção:	Computational and Structural Biotechnology Journal
Assuntos:	Mutation Coolspots Mycobacterium leprae In-silico Saturation Mutagenesis Thermodynamic stability Rifampin RNA Polymerase
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2001037019302910
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