Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo

ABSTRACT Neuraminidase (NA) is a pivotal surface enzyme and a key therapeutic target in combating the influenza A virus. Its evolution can lead to potential zoonotic transmission, seasonal epidemics, and the emergence of drug-resistant mutants. To gain comprehensive insights into the mutational effe...

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Bibliographic Details

Main Authors:	Sihan Wang, Tian-hao Zhang, Menglong Hu, Kejun Tang, Li Sheng, Mengying Hong, Dongdong Chen, Liubo Chen, Yuan Shi, Jun Feng, Jing Qian, Lifeng Sun, Kefeng Ding, Ren Sun, Yushen Du
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2023-10-01
Series:	mSystems
Subjects:	deep mutational scanning drug-resistant mutations influenza neuraminidase
Online Access:	https://journals.asm.org/doi/10.1128/msystems.00670-23
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