Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) – comprising the four eIF2α kinases PERK, GCN2, PKR, an...

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Autori principali:	Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J Bollong, Timothy E Shutt, Danielle A Grotjahn, R Luke Wiseman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2025-02-01
Serie:	eLife
Soggetti:	integrated stress response mitochondrial morphology mitochondrial fragmentation stress signaling
Accesso online:	https://elifesciences.org/articles/100541
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