Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) – comprising the four eIF2α kinases PERK, GCN2, PKR, an...

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Bibliographic Details

Main Authors:	Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J Bollong, Timothy E Shutt, Danielle A Grotjahn, R Luke Wiseman
Format:	Artigo
Language:	Inglês
Published:	eLife Sciences Publications Ltd 2025-02-01
Series:	eLife
Subjects:	integrated stress response mitochondrial morphology mitochondrial fragmentation stress signaling
Online Access:	https://elifesciences.org/articles/100541
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