Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.

Bibliografiske detaljer

Principais autores:	M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-06-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-020-16984-1
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