Model‐Informed Recommendation of Mavacamten Posology for Chinese Adults With Obstructive Hypertrophic Cardiomyopathy

ABSTRACT Mavacamten is a cardiac myosin inhibitor for adults with obstructive hypertrophic cardiomyopathy (HCM). Dose optimization is performed 4 weeks after starting mavacamten, guided by periodic echo measurements of Valsalva left ventricular outflow tract gradient (VLVOTg) and left ventricular ej...

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Váldodahkkit:	Xiaojie Wu, Shilpa Puli, Nanye Chen, Zhuang Tian, Peiwen Hsu, Jing Sun, Cheng Lyu, Samira Merali, Jing Zhang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Wiley 2025-04-01
Ráidu:	CPT: Pharmacometrics & Systems Pharmacology
Fáttát:	dose efficacy ethnicity exposure response model evaluation model‐based drug development
Liŋkkat:	https://doi.org/10.1002/psp4.13312
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